Artificial Intelligence for Multiple Sclerosis Management Using Retinal Images: Pearl, Peaks, and Pitfalls
@article{FarabiMaleki2023ArtificialIF, title={Artificial Intelligence for Multiple Sclerosis Management Using Retinal Images: Pearl, Peaks, and Pitfalls}, author={Shadi Farabi Maleki and Milad Yousefi and Sayeh Afshar and Siamak Pedrammehr and Chee Peng Lim and Ali Jafarizadeh and Houshyar Asadi}, journal={Seminars in Ophthalmology}, year={2023}, volume={39}, pages={271 - 288}, url={https://api.semanticscholar.org/CorpusID:266226997} }
This study reviews the current research studies on the integration of AI, including ML and DL algorithms, with OCT in the context of MS, and examines the advancements, challenges, potential prospects, and ethical concerns of AI-powered techniques in enhancing MS diagnosis, monitoring disease progression, revolutionizing patient care, the development of patient screening tools, and supported clinical decision-making based on OCT images.
Topics
Optical Coherence Tomography (opens in a new tab)Deep Learning (opens in a new tab)Retinal Images (opens in a new tab)Disability Progression (opens in a new tab)Clinical Decision-making (opens in a new tab)Machine Learning (opens in a new tab)MS Subtypes (opens in a new tab)Artificial Intelligence (opens in a new tab)
16 Citations
Deep Learning and The Retina: A New Frontier in Multiple Sclerosis Diagnosis
- 2025
Medicine, Computer Science
Artificial intelligence-enhanced retinal imaging is emerging as a powerful, non-invasive tool that can complement traditional neurological assessments and support earlier, more personalized MS care.
Deep learning for multiple sclerosis lesion classification and stratification using MRI
- 2025
Medicine, Computer Science
Retinal imaging and Alzheimer's disease: a future powered by Artificial Intelligence.
- 2024
Medicine, Computer Science
The growing application of AI in medicine promises its future position in processing different aspects of patients with AD, but there needs cohort studies to determine whether it can help to follow up with healthy persons at risk of AD for a quicker diagnosis or assess the prognosis of patients with AD.
Artificial intelligence in assessing cardiovascular diseases and risk factors via retinal fundus images: A review of the last decade
- 2024
Medicine, Computer Science
An overview of the recent developments and difficulties in using AI and retinal imaging to diagnose cardiovascular diseases is provided and provides insights for further exploration in this field.
MRI-based detection of multiple sclerosis using an optimized attention-based deep learning framework.
- 2025
Medicine, Computer Science
The 2DRK-MSCAN framework offers a reliable and effective solution for early MS detection using MRI, and shows promising potential for aiding timely intervention and improving patient care.
Current and future roles of artificial intelligence in retinopathy of prematurity
- 2025
Medicine, Computer Science
It is concluded that traditional methods for ROP diagnosis suffer from subjectivity and manual analysis, leading to inconsistent clinical decisions, and AI holds great promise for improving ROP management.
Artificial intelligence for early detection of diabetes mellitus complications via retinal imaging
- 2025
Medicine, Computer Science
Retinal images can be used to diagnose DM complications including DR, neuropathy, nephropathy, and atherosclerotic cardiovascular disease, as well as to predict the risk of cardiovascular events, and have the potential to become a central tool for modern personalized medicine in patients with DM.
Retinal alterations induced by amyotrophic lateral sclerosis: An analysis using optical coherence tomography
- 2025
Medicine
Clinical Applications of Artificial Intelligence in Neurology Practice
- 2025
Medicine, Computer Science
Some of the potential applications of artificial intelligence in health care and neurology clinical practice are explored, with a focus on improving diagnostic testing, documentation, and clinical workflows and highlighting opportunities to address long-standing human biases and challenges and potential mitigation strategies.
Artificial Intelligence-Assisted Design of Nanomedicines for Breast Cancer Diagnosis and Therapy: Advances, Challenges, and Future Directions
- 2025
Medicine, Engineering
The study emphasizes the need for multidisciplinary collaboration to eliminate existing barriers and generate advancements to transform breast cancer therapies into more effective, safer, and individualized methods.
94 References
Diagnosis of multiple sclerosis using optical coherence tomography supported by artificial intelligence.
- 2023
Medicine, Engineering
Machine learning in diagnosis and disability prediction of multiple sclerosis using optical coherence tomography
- 2021
Medicine, Computer Science
Multiple Sclerosis Diagnosis Using Machine Learning and Deep Learning: Challenges and Opportunities
- 2022
Medicine, Computer Science
The challenges faced by automated MS diagnosis include difficulty distinguishing the disease from other diseases showing similar symptoms, protecting the confidentiality of the patients’ data, achieving reliable ML models that are also easily understood by non-experts, and the difficulty of collecting a large reliable dataset.
Deep Learning-Based Method to Differentiate Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis
- 2020
Medicine, Computer Science
The proposed model was verified to be capable of differentiating NMOSD from MS with accuracy comparable to that of neurologists, exhibiting the advantage of consistent classification.
Machine learning classification of multiple sclerosis in children using optical coherence tomography
- 2022
Medicine
This study demonstrates that ML based on OCT features can be used to support a diagnosis of MS in children with demyelinating diseases.
Swept source optical coherence tomography to early detect multiple sclerosis disease. The use of machine learning techniques
- 2019
Medicine
Measurements of RNFL thickness obtained with SS-OCT have an excellent ability to differentiate between healthy controls and patients with MS, and machine learning techniques based on these measures can be a reliable tool to help in MS diagnosis.
Artificial intelligence in the diagnosis of multiple sclerosis: A systematic review.
- 2022
Medicine, Computer Science
Diagnostic performance of artificial intelligence in multiple sclerosis: a systematic review and meta-analysis
- 2022
Medicine, Computer Science
The results indicate that the use of AI can aid the clinicians in accurate diagnosis of MS and improve current diagnostic approaches as most of the parameters including accuracy, sensitivity, specificity, precision, and AUC were considerably high, especially when using MRI data.
Discrimination of multiple sclerosis using OCT images from two different centers.
- 2023
Medicine, Engineering
Subclinical anterior optic pathway involvement in early multiple sclerosis and clinically isolated syndromes.
- 2021
Medicine
The present study suggests that instrumental evidence of subclinical optic nerve involvement is associated with a greater disease burden in clinically isolated syndrome, and challenges the current hypothesis that the inner nuclear layer is an acute phase marker of inflammatory activity.