An electrochemical method for the determination of liposome-water partition coefficients of drugs
@article{Ikonen2007AnEM, title={An electrochemical method for the determination of liposome-water partition coefficients of drugs}, author={Marjukka Ikonen and Lasse Murtom{\"a}ki and Ky{\"o}sti Kontturi}, journal={Journal of Electroanalytical Chemistry}, year={2007}, volume={602}, pages={189-194}, url={https://api.semanticscholar.org/CorpusID:26215802} }
36 Citations
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31 References
Determination of liposome partitioning of ionizable drugs by titration.
- 1999
Chemistry, Medicine
A fast pH-metric titration method for the determination of liposome partitioning of ionizable drugs using small unilamellar phosphatidylcholine vesicles prepared by sonic homogenization has been successfully developed, enabling the use of high lipid-to-drug ratios.
Electrochemical determination of partition coefficients of drugs.
- 1992
Chemistry, Medicine
An electrochemical method for the determination of partition coefficients of drugs that can exist as ions in aqueous solutions is presented and 1,2-dichloroethane, which has electronic properties similar to those of n-octanol, was used in the measurements.
pH-Metric logP 10. Determination of Liposomal Membrane-Water Partition Coefficients of lonizable Drugs
- 2004
Chemistry, Medicine
It has been shown that the liposomal membrane-water partition coefficients as derived from the pH-metric technique are consistent with those obtained from alternative methods such as ultrafiltration and dialysis.
Water-Oil Partition Profiling of Ionized Drug Molecules Using Cyclic Voltammetry and a 96-Well Microfilter Plate System
- 2004
Chemistry, Medicine
The procedure based on 96-well microfilter plates with microporous filters to support 96 organic liquid membranes is shown to be useful for determining logP of ionized drugs in a rapid and efficient way.
Molecular Factors Influencing Retention on Immobilized Artificial Membranes (IAM) Compared to Partitioning in Liposomes and n-Octanol
- 2004
Chemistry
When hydrophobic interactions dominate retention, IAM capacity factors are well correlated with liposomal partitioning, and on the contary, for hydrophilic solutes, the two systems do not yield the same information and are not interchangeable.
Thermodynamics of partitioning of β-blockers in the n-octanol- buffer and liposome systems
- 1987
Chemistry, Medicine
The pH-Dependence in the Partitioning Behaviour of (RS)-[3H]Propranolol Between MDCK Cell Lipid Vesicles and Buffer
- 2004
Chemistry, Medicine
The partitioning behaviour of (RS)-[3H]propranolol in a complex membrane/buffer system can be described when considering ionisation changes of drug and lipids.
Combined quantitative and mechanistic study of drug-membrane interactions using a novel 2H NMR approach.
- 2004
Chemistry, Medicine
A new ( 2)H nuclear magnetic resonance (NMR) approach has been developed here that quantifies the affinity of (2)H-labeled small molecules for different phospholipid membranes and, simultaneously, provides information on the mechanism of the drug-membrane interaction.
Peptide binding to lipid bilayers. Binding isotherms and zeta-potential of a cyclic somatostatin analogue.
- 1990
Chemistry, Medicine
The binding of the cyclic somatostatin analogue SMS 201-995 to neutral and negatively charged lipids was investigated with a centrifugation assay and with electrophoretic and monolayer methods, showing a parallel alignment of the peptide long axis with the membrane surface.