Dissociation in prefrontal cortex of affective and attentional shifts

@article{Dias1996DissociationIP,
  title={Dissociation in prefrontal cortex of affective and attentional shifts},
  author={Rebecca Dias and Trevor William Robbins and Angela C. Roberts},
  journal={Nature},
  year={1996},
  volume={380},
  pages={69-72},
  url={https://api.semanticscholar.org/CorpusID:4301013}
}
It is demonstrated that disinhibition, or a loss of inhibitory control, can be selective for particular cognitive functions and that different regions of the prefrontal cortex provide inhibitory Control in different aspects of cognitive processing.
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14 References

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The results suggest that the gross set-shifting deficits reported in both frontal lobe patients and patients with Parkinson's disease may involve fundamentally different, though related, cognitive processes, and that these may be differentially affected by medication.

Monitoring of selections of visual stimuli and the primate frontal cortex

    M. Petrides
    Biology
    Proceedings of the Royal Society of London…
  • 1991
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