A Draft Sequence of the Neandertal Genome
The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.
Genetic history of an archaic hominin group from Denisova Cave in Siberia
A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.
A High-Coverage Genome Sequence from an Archaic Denisovan Individual
- M. MeyerMartin Kircher S. Pääbo
- 12 October 2012
Biology
The genomic sequence provides evidence for very low rates of heterozygosity in the Denisova, probably not because of recent inbreeding, but instead because of a small population size, and illuminates the relationships between humans and archaics, including Neandertals, and establishes a catalog of genetic changes within the human lineage.
The complete genome sequence of a Neandertal from the Altai Mountains
- Kay PrüferF. Racimo S. Pääbo
- 18 December 2013
Biology, History
It is shown that interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene and a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans is established.
Whole-genome analyses resolve early branches in the tree of life of modern birds
- E. JarvisS. Mirarab Guojie Zhang
- 12 December 2014
Biology, Environmental Science
A genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves recovered a highly resolved tree that confirms previously controversial sister or close relationships and identifies the first divergence in Neoaves, two groups the authors named Passerea and Columbea.
The Transcriptional Landscape of the Mammalian Genome
- Piero CarninciT. Kasukawa Y. Hayashizaki
- 2 September 2005
Biology
Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans
- B. P. LewisR. GreenS. Brenner
- 26 December 2002
Biology
It is proposed that regulated unproductive splice and translation (RUST), through the coupling of alternative splicing and NMD, may be a pervasive, underappreciated means of regulating protein expression.
Chromosome-scale shotgun assembly using an in vitro method for long-range linkage
- Nicholas H. PutnamBrendan L. O’Connell R. Green
- 18 February 2015
Biology, Computer Science
A simpler approach (“Chicago”) based on in vitro reconstituted chromatin, which can identify poor quality joins and produce accurate, long-range sequence scaffolds and is demonstrated for improving existing assemblies by reassembling and scaffolding the genome of the American alligator.
Analysis of one million base pairs of Neanderthal DNA
A 38,000-year-old Neanderthal fossil that is exceptionally free of contamination from modern human DNA is identified and it is revealed that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago.
Comparative genomics reveals insights into avian genome evolution and adaptation
- Guojie ZhangCai Li Emanuel Maldonado
- 12 December 2014
Biology, Environmental Science
This work explored bird macroevolution using full genomes from 48 avian species representing all major extant clades to reveal that pan-avian genomic diversity covaries with adaptations to different lifestyles and convergent evolution of traits.
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