Water-Oil Partition Profiling of Ionized Drug Molecules Using Cyclic Voltammetry and a 96-Well Microfilter Plate System

@article{Ulmeanu2003WaterOilPP,
  title={Water-Oil Partition Profiling of Ionized Drug Molecules Using Cyclic Voltammetry and a 96-Well Microfilter Plate System},
  author={Sorina M. Ulmeanu and Henrik Jensen and G{\'e}raldine Bouchard and Pierre-Alain Carrupt and Hubert H. Girault},
  journal={Pharmaceutical Research},
  year={2003},
  volume={20},
  pages={1317-1322},
  url={https://api.semanticscholar.org/CorpusID:9917932}
}
The procedure based on 96-well microfilter plates with microporous filters to support 96 organic liquid membranes is shown to be useful for determining logP of ionized drugs in a rapid and efficient way.

Electrochemical study of the anticancer drug daunorubicin at a water/oil interface: drug lipophilicity and quantification.

The ion transfer mechanism of the anticancer drug daunorubicin (DNR) at a liquid/liquid interface has been studied for the first time using electrochemical techniques and the results obtained were presented in the form of an ionic partition diagram.

Mechanism of Ion Transfer in Supported Liquid Membrane Systems: Electrochemical Control over Membrane Distribution

The observed double-transfer voltammogram, although it has been largely neglected in previous literature, is a logical consequence of the presence of two liquid–liquid interfaces and is rationalized in terms of ion transfer across the two interfaces on either side of the membrane.

Electrochemical Analysis and Applications of Tetracycline Transfer Reaction Process at Liquid/liquid Interfaces

The transfer reaction characteristics of tetracycline (TC) across a polarized water/1,2-dichloroethane (1,2-DCE) interface was studied via controlling both pH and ionic strength of the aqueous phase

Liquid/Liquid Interfaces, Electrochemistry at

This article outlines the electrochemical methodology at the interface between two immiscible electrolyte solutions (ITIES). The fundamental concepts of the thermodynamics in biphasic systems are

Electromembrane extraction: Distribution or electrophoresis?

The results demonstrated for the first time that EME behaved like a distribution system, with voltage dependent distribution coefficients, and electrokinetic migration was observed across the SLM, which added an electrophoretic component to the mass transfer.

Double-Polymer-Modified Pencil Lead for Stripping Voltammetry of Perchlorate in Drinking Water

The inexpensive and disposable electrode based on a double-polymer-modified pencil lead is proposed for upper-division undergraduate instrumental laboratories to enable the highly sensitive detection

Lipophilicity and solvation of anionic drugs.

The parameter diff (log P(N-A)(dce) was shown to depend not only on intramolecular interactions and conformational effects in the neutral and anionic forms, but also on the delocalization of the negative charge in the anion, confirming the ability of Born's solvation model to describe qualitatively the effect of the molecular radius on the lipophilicity of ions.

pH-Metric logP 10. Determination of Liposomal Membrane-Water Partition Coefficients of lonizable Drugs

It has been shown that the liposomal membrane-water partition coefficients as derived from the pH-metric technique are consistent with those obtained from alternative methods such as ultrafiltration and dialysis.

Charge and Delocalisation Effects on the Lipophilicity of Protonable Drugs

Born's solvation model is used to illustrate qualitatively the effect of the molecular radius on the lipophilicity and to show that ions retain more water molecules when they transfer into octanol than into 2,2-dichloroethane, and how ionisable compounds can modulate the pH.

Structure-Lipophilicity Relationships of Neutral and Protonated β-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems

Derived parameters such as Δlog P and diff (difference between log P in two different solvent systems, a parameter valid for a given solute in a given electrical form) yielded insights into inter- and intramolecular interactions characteristic of β-blockers.

Effects of charge and intramolecular structure on the lipophilicity of nitrophenols

The lipophilicity of a series of phenolic compounds was studied in the 1,2-dichloroethane (1,2-DCE)/water system. Cyclic voltammetry at the ITIES was used to study the transfer characteristics of the

Measurement of partition coefficients in waterless biphasic liquid systems by countercurrent chromatography.

Countercurrent chromatography (CCC) is a chromatographic separation technique that uses a liquid as a stationary phase to quantify the solvent selectivity toward aromatic extraction.

Lipophilicity of the nitrophenols

Results are confirmed by ab initio calculations which show that 2,3- and 2,6-dinitrophenol and picric acid are significantly distorted away from planarity, which apparently disrupts their internal hydrogen bonding.

High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.

Alkane/water partition coefficients can be derived from intrinsic membrane permeabilities, making this assay the first high-throughput method able to measure alkane/ water log P in the microtiterplate format.