Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

@article{Zhu2019RoleAM,
  title={Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage},
  author={Huimin Zhu and Zhiqiang Wang and Jixu Yu and Xiuli Yang and Feng He and Zhenchuan Liu and Fengyuan Che and Xuemei Chen and Honglei Ren and Michael Hong and Jian Wang},
  journal={Progress in Neurobiology},
  year={2019},
  volume={178},
  url={https://api.semanticscholar.org/CorpusID:85495400}
}
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256 Citations
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256 Citations

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This review summarizes the latest advances in the study of chemokine functions in the ICH and point to therapeutic opportunities targeting chemokines productions and interactions in treating ICH, such as accelerating hematoma absorption and alleviating brain edema.

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The respective characteristics of immune cells and their interactions in neuroimmune inflammation are delve into, and favorable immunotherapeutic approaches regarding ICH are elucidated, and an outlook is presented.

Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

Some key pathophysiology mechanisms in ICH such as oxidative stress, inflammation, iron toxicity, and thrombin formation are discussed and the corresponding therapeutic targets and therapeutic strategies are reviewed.

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An update of recent progress on ICH is provided and the prospects for further preclinical studies in this field are described and new therapeutic targets and directions for the treatment of ICH are discussed.

Molecular, Pathological, Clinical, and Therapeutic Aspects of Perihematomal Edema in Different Stages of Intracerebral Hemorrhage

This review summarizes the factors that affect Perihematomal edema by focusing on traditional variables, the cerebral venous drainage system, and the brain lymphatic drainage system and summarizes the factors that affect PHE by focusing on traditional variables.

Microglia Phenotype and Intracerebral Hemorrhage: A Balance of Yin and Yang

The dual functions of microglia in the brain after an ICH from immunological perspective are discussed, the activation mechanism of perihematomalmicroglia is elaborate, and related therapeutic drugs researches are summarized.

Pathological mechanisms and future therapeutic directions of thrombin in intracerebral hemorrhage: a systematic review

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Mechanism and Regulation of Microglia Polarization in Intracerebral Hemorrhage

The mechanism of action of microglia’s M1 and M2 phenotypes in secondary brain injury after ICH is reviewed and compounds and natural pharmaceutical ingredients that can polarize the M1 to the M2 phenotype are discussed.

MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy

The pathophysiological roles and molecular underpinnings of miRNAs in the regulation of neuroinflammation after ICH are addressed and the possibility of applying miRNA-based therapeutics for this disease is indicated.

Neuroinflammation and iron metabolism after intracerebral hemorrhage: a glial cell perspective

This review aims to explore neuroinflammation from the perspective of iron metabolism, linking the complex pathophysiological changes, delving into the exploration of treatment approaches for ICH, and offering insights that could enhance clinical management strategies.
...

368 References

Inflammation after Intracerebral Hemorrhage

In this review, a summary of the available literature on the inflammatory responses after ICH is presented along with discussion of some of the emerging opportunities for potential therapeutic strategies.

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

Neuroinflammation after intracerebral hemorrhage

Little is currently known about the interactions among different immune cell populations in the setting of ICH, Nevertheless, immunomodulatory strategies are already being explored in ICH.

Preclinical and clinical research on inflammation after intracerebral hemorrhage

Serum biomarkers of spontaneous intracerebral hemorrhage induced secondary brain injury

Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage

The role of microglial activation/polarization and related inflammatory mediators, such as Toll-like receptor 4, matrix metalloproteinases, high-mobility group protein box-1, nuclear factor erythroid 2-related factor 2, heme oxygenase, and iron, in secondary injury after ICH is discussed and the potential targets for ICH treatment are highlighted.

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

Some promising advances are summarized in the field of oxidative stress and ICH, including contained animal and human investigations, and some research of potential therapeutic options aimed at reducing oxidative stress to protect the neuronal function after ICH.

Inflammatory responses after intracerebral hemorrhage: From cellular function to therapeutic targets

The search for effective immunotherapy to target specific cell type-mediated inflammation might represent a new direction for intracerebral hemorrhage treatment, separate from traditional anti-inflammatory drug discovery.

Re-exploring Tumor Necrosis Factor Alpha as a Target for Therapy in Intracerebral Hemorrhage

A reasonable body of evidence from experimental models of ICH suggests that upregulation of TNF-α adjacent to the hematoma is associated with increased peri-hematomal edema, and that inhibition of T NF-α attenuates the formation and progression of this edema and ultimately improves outcomes.

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Current knowledge of ICH pathogenesis and problems arising with respect to exploration of new drug candidates are discussed.
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