Use of Stimulants in Bipolar Disorder

@article{Perugi2017UseOS,
  title={Use of Stimulants in Bipolar Disorder},
  author={Giulio Perugi and Giulia Vannucchi and F. Bedani and Ettore Favaretto},
  journal={Current Psychiatry Reports},
  year={2017},
  volume={19},
  pages={1-9},
  url={https://api.semanticscholar.org/CorpusID:2932701}
}
The aims are to summarize available literature on the use of stimulants in bipolar patients, discuss practical management implications, and suggest MPH might be an option in some bipolar forms observed in psychiatric presentations of frontotemporal dementia and traumatic brain injury.
View on Springer Nature
link.springer.com
45 Citations
Background Citations
11
Methods Citations
2

45 Citations

Use of Stimulants for ADHD and TBI in Veterans

The authors review the most common psychiatric conditions for which stimulants may be indicated in veterans as well as tips for successful prescribing practices, monitoring ongoing use, and potential pitfalls and contraindications.

Risk of Mania After Methylphenidate in Patients With Bipolar Disorder

Initiation of methylphenidate treatment was not associated with an increased risk of mania in patients with bipolar disorder, and a decrease in mania, depressive episodes, and psychiatric admissions was observed afterethylphenidate.

Adjunctive treatment with psychostimulants and stimulant-like drugs for resistant bipolar depression: a systematic review and meta-analysis

Treatment guidelines should be revised to include these medications earlier in the therapeutic algorithm for resistant acute bipolar depression, as LDX, modafinil, and armodafinIL seem to offer a reasonably well-tolerated and safe treatment in resistant bipolar depression.

Adverse effects of stimulant medications in children and adolescents: focus on drug abuse

ADHD With Comorbid Bipolar Disorders: A Systematic Review of Neurobiological, Clinical And Pharmacological Aspects Across The Lifespan.

A systematic review of the scientific literature on the neurobiological, clinical features and current pharmacological management of ADHD comorbid with BDs across the entire lifespan, with a major focus on the adulthood.

Bipolar depression: a review of treatment options

Bipolar depression (BD-D) is both common and incredibly challenging to treat. Even treated individuals with BD-D experience depression approximately 19% of the time, and subsyndromal depression an…

Methylphenidate in the Treatment of Medication Induced Excessive Daytime Sleepiness: A Unique Case Report and Review of Literature

A 56-year old male with a long history of bipolar I and anxiety disorders finally stabilized after multiple medications trials with a combination of different psychotropic medications, including mood stabilizers and benzodiazepine using low dose methylphenidate.

Comorbidities in Youth with Bipolar Disorder: Clinical Features and Pharmacological Management

Developmentally-sensitive controlled clinical trials are warranted to improve the prognosis of these highly complex patients, requiring timely and finely personalized therapies.

Triple Diagnosis of Attention-Deficit/Hyperactivity Disorder with Co-existing Bipolar and Alcohol Use Disorders: Clinical Aspects and Pharmacological Treatments

Clinical experience and scientific evidence show that tailoring treatments for these three conditions considering their co-occurrence as a sole complex disorder yields more fulfilling and durable clinical outcomes.

Management Strategies for Borderline Personality Disorder and Bipolar Disorder Comorbidities in Adults with ADHD: A Narrative Review

This narrative review examines two of the common comorbidities of attention-deficit/hyperactivity disorder, bipolar disorder (BD), and borderline personality disorder (BPD), which each share several…

83 References

Naturalistic Long-term Use of Methylphenidate in Bipolar Disorder

Methylphenidate seems to be safe in the naturalistic setting and controlled studies are needed to confirm its efficacy and safety in bipolar depression, especially in children with comorbid bipolar and attention-deficit disorder.

The use of stimulants and atomoxetine in adults with comorbid ADHD and bipolar disorder

Although systematic trials on the use of stimulants and ATX in ADHD-BD comorbidity in adulthood are necessary, both treatments should be considered possible options to be carefully evaluated once the patient has been stabilized.

Adjunctive stimulant use in patients with bipolar disorder: treatment of residual depression and sedation.

The present case series suggests that adjunctive stimulants may be a reasonable therapeutic option for treating residual depression and medication-induced sedation in some patients with bipolar disorder.

Adjunctive Methylphenidate in the Treatment of Bulimia Nervosa Co-occurring with Bipolar Disorder and Substance Dependence.

A young woman with bulimia nervosa, bipolar I disorder, cocaine and alcohol dependence, attention-deficit hyperactivity disorder, and panic disorder who achieved a sustained (>1 year) remission of her bulimIA nervosa symptoms and significant improvement of her attention- deficit hyper activity disorder symptoms with adjunctive methylphenidate is described.

Mood Stabilizers in the Treatment of Substance Use Disorders

Valproate appears to be a potentially fruitful medication to study in these dual diagnosis patients due to preliminary evidence demonstrating its anticraving efficacy.

The Management of Catatonia in Bipolar Disorder with Stimulants

A married Caucasian male with a history of bipolar disorder, exhibiting catatonia and experiencing difficulty in day-to-day functioning is presented, who only displayed significant clinical improvement with the addition of a stimulant, methylphenidate.

Modafinil for Remitted Bipolar Depression with Hypersomnia

Modafinil may be a well-tolerated and effective alternative to conventional stimulants in the treatment of hypersomnia, especially in bipolar disorder, where there is considerable risk of switch to mania with stimulant medications.

Gabapentin and methylphenidate treatment of a preadolescent with attention deficit hyperactivity disorder and bipolar disorder.

A 12-year-old boy with a history of attention deficient hyperactivity disorder, reading disorder, mixed receptive and expressive language disorder, encopresis, and bipolar disorder II who was treated with gabapentin 200mg/day added to methylphenidate 30 mg/day within 3 weeks the improvement and stabilization of mood symptoms was remarkable, as noted by mother, teacher, and clinician.

Frequency of stimulant treatment and of stimulant-associated mania/hypomania in bipolar disorder patients.

This is the largest study on amphetamine/ methylphenidate treatment and associated mania/hypomania in BD patients and finds absence of axis-I comorbidity was associated with stimulant-associated mania.

An open study of methylphenidate in bipolar depression.

In this brief, open study, methylphenidate was effective and relatively safe in depressed bipolar subjects and was shown to reduce manic behavior.
...