137 Citations
Bayesian Modeling of Epigenetic Variation in Multiple Human Cell Types
- 2015
Biology, Computer Science
A unified Bayesian framework for jointly annotating multiple epigenomes and detecting differential regulation among multiple tissues and cell types over regions of varying sizes is developed, which achieves superior power and accuracy over existing methods.
Estimating Statistical Measures of Pleiotropic and Epistatic Effects in the Genomic Era
- 2014
Biology, Mathematics
Ability to use working definitions of alleles to identify the genotype of each individual in a sample results in a significant change in the working paradigm of sub-field of quantitative genetics, called variance and covariance analysis, because effects and components of variance and covance may be estimated directly in a sense that will be described in detail in the paper.
Proposal for a Center for the determination of the Causal Transcriptional Consequences of Human
- 2009
Biology
Development Of Molecular Epidemiological Tools For Better Understanding And Control Of Buruli Ulcer
- 2013
Medicine, Biology
Synthetic DNA applications in information technology
- 2022
Computer Science, Biology
An overview of the most prevalent applications of synthetic DNA that could shape the future of information technology and the reasons why the biomolecule can be a valuable alternative for conventional electronic-based media are emphasized.
Future of Personalized Medicine
- 2020
Medicine
Each chapter on therapeutic areas of the personalized medicine has a section on future at the end to highlight the important advances anticipated by the year 2025 that are relevant to personalized medicine.
Transcriptional response to host chemical cues underpins expansion of host range in a fungal plant pathogen lineage
- 2020
Biology, Environmental Science
This work demonstrates adaptive plasticity of a broad host range pathogen with specific responses to different host plants and demonstrates the co-existence of signatures for generalist and polyspecialist life styles in the genome of a plant pathogen.
Secuenciación de ADN mediante un algoritmo basado en hidden Markov models para el dispositivo MinION
- 2020
Los dispositivos MinION son secuenciadores modernos que se caracterizan por su precio y dimensiones bajos respecto a los secuenciadores anteriores. Por estas razones es visto con entusiasmo por…
Ancient DNA From Museum Specimens and Next Generation Sequencing Help Resolve the Controversial Evolutionary History of the Critically Endangered Puebla Deer Mouse
- 2020
Biology, Environmental Science
This study demonstrates that high-throughput sequencing of ancient DNA, appropriately controlling for contamination and degradation, can provide a robust resolution of the evolutionary history and taxonomic status of species for which few or no modern genetic samples exist.