Allopregnanolone and mood disorders
@article{Bckstrm2014AllopregnanoloneAM,
title={Allopregnanolone and mood disorders},
author={Torbj{\"o}rn B{\"a}ckstr{\"o}m and Marie Bixo and Maja Johansson and Sigrid Nyberg and Lindsey Ossewaarde and Gianna Ragagnin and Ivanka Savic and Jessica Str{\"o}mberg and Erika Timby and Frank van Broekhoven and Guido A. van Wingen},
journal={Progress in Neurobiology},
year={2014},
volume={113},
pages={88-94},
url={https://api.semanticscholar.org/CorpusID:207407084}
}183 Citations
GABAA Receptor-Modulating Steroids in Relation to Women’s Behavioral Health
- 2015
Medicine, Psychology
In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD), and this effect can be induced by all GABAA receptor modulators in low concentrations whereas higher concentrations are calming.
Effects of GABA active steroids in the female brain with a focus on the premenstrual dysphoric disorder
- 2018
Medicine, Biology
The underlying studies of this review provide evidence that allopregnanolone is the provoking factor behind the negative mood symptoms in PMDD and that isoallopreg nanolone could ameliorate the symptoms as a result of its ability to antagonise the allopreginolone effect on the GABAA receptor.
Progesterone and Its Metabolites Play a Beneficial Role in Affect Regulation in the Female Brain
- 2023
Medicine
A new understanding of progesterone-related mood disorders can translate the study results from case series and observational studies to cohort studies, clinical trials, and novel, effective treatment protocols being developed.
GABA-ergic Modulators: New Therapeutic Approaches to Premenstrual Dysphoric Disorder
- 2023
Medicine, Psychology
Promising findings from early clinical trials of several compounds that stabilize allopregnanolone signaling during the luteal phase of the menstrual cycle are explored, and GABAergic interventions in PMDD can be used to better understand the relationship between mood states, network regulation, and the balance between excitatory and inhibitory signaling in the brain.
Polycystic Ovary Syndrome, Affective Symptoms, and Neuroactive Steroids: a Focus on Allopregnanolone
- 2021
Medicine, Psychology
Prospective studies evaluating associations between psychiatric symptoms and NAS are needed to elucidate the biological causes of the increased rates of psychiatric symptoms among women with PCOS and inform clinical treatment, and allopregnanolone, with its role in normal reproductive function, menstrual dysregulation, makes it a particularly intriguing candidate for future investigation.
Response to sertraline is associated with reduction in anxiety-potentiated startle in premenstrual dysphoric disorder
- 2021
Psychology, Medicine
Altered alterations in APS suggest potential GABA-A-R changes across the menstrual cycle and in response to sertraline among treatment responders, suggesting impaired ability to modulate arousal reactivity.
Allopregnanolone and reproductive psychiatry: an overview
- 2019
Medicine, Psychology
An overview of the relationship between allopregnanolone and mood at menarche, in the menstrual cycle; in the peripartum; and in the menopausal transition finds ALLO dysregulation is identified in all of these transitions and found to be associated with mood symptoms.
Hormonal Contraception and Depression: Updated Evidence and Implications in Clinical Practice
- 2020
Medicine, Psychology
An update of the literature on the possible appearance of depressive symptoms when using hormonal contraceptives is provided, and the possible explanations of this problem are investigated based on animal and human studies.
The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies
- 2022
Medicine, Biology
The blunted allopregnanolone response to acute stress, often observed in female rats and women, may represent one of the mechanisms that contribute to the increased vulnerability to stress and affective disorders in women under the different hormonal fluctuations that occur throughout their lifespan.
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