Genetic composition of Brazilian population samples based on a set of twenty‐eight ancestry informative SNPs

@article{Lins2009GeneticCO,
  title={Genetic composition of Brazilian population samples based on a set of twenty‐eight ancestry informative SNPs},
  author={T{\'u}lio Cesar Lins and Rodrigo G. Vieira and Breno Silva de Abreu and Dario Grattapaglia and Rinaldo Wellerson Pereira},
  journal={American Journal of Human Biology},
  year={2009},
  volume={22},
  url={https://api.semanticscholar.org/CorpusID:205301927}
}
Analysis of information content of 28 ancestry‐informative SNPs into multiplexed panels using three parental population sources to infer the genetic admixture in an urban sample of the five Brazilian geopolitical regions suggested little genetic differentiation between the South and the remaining regions.
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158 Citations
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158 Citations

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48 References

Color and Genomic Ancestry in Brazilians: A Study with Forensic Microsatellites

The present investigation based on data from 12 commercially available forensic microsatellites corroborate and validate previous conclusions that in Brazil at the individual level there is significant dissociation of color and genomic ancestry.

Ancestry informative markers in Amerindians from Brazilian Amazon

Although capable of differentiating tribes, a neighbor‐joining tree suggests that the AIMs are useless in obtaining reliable reconstructions of the biological relationships and evolutionary history that characterize the villages and tribes studied.

Color and genomic ancestry in Brazilians

The data suggest that in Brazil, at an individual level, color, as determined by physical evaluation, is a poor predictor of genomic African ancestry, estimated by molecular markers.

Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America

It is concluded that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations.

Admixture and Population Stratification in African Caribbean Populations

Significant substructure was observed in the islands of Jamaica and St. Thomas but not Barbados, indicating that differences in population substructure exist across these three Caribbean islands, and these differences may have significant ramifications for case‐control studies of complex disease in Caribbean populations.

Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populations

It is demonstrated that approximately 100 ancestry informative markers (AIMs) are required to obtain estimates of ancestry that correlate with correlation coefficients more than 0.9 with the true individual ancestral proportions.

Self-reported skin color, genomic ancestry and the distribution of GST polymorphisms

Interethnic admixture is a source of cryptic population structure that may lead to spurious genotype–phenotype associations in pharmacogenetic/-genomic studies and logistic regression modeling of GST polymorphisms shows that admixture must be dealt with as a continuous variable, rather than proportioned in arbitrary subcategories for the convenience of data quantification and analysis.

Heterogeneity of the genome ancestry of individuals classified as White in the State of Rio Grande do Sul, Brazil

The results indicate that Brazilian populations are remarkably heterogeneous; while some present an overwhelming majority of transplanted European genomes, with a complete correspondence between physical appearance and ancestry, others reflect a history of extensive admixture with dissociation between physical appearances and ancestry.

Admixture in Mexico City: implications for admixture mapping of Type 2 diabetes genetic risk factors

This work characterized the admixture proportions in a sample of 286 unrelated T2D patients and 275 controls from Mexico City and discussed the implications of the results for admixture mapping studies.

Argentine population genetic structure: large variance in Amerindian contribution.

The large variance in admixture proportions in individual Argentine subjects shows that this population is appropriate for future admixture mapping studies and provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification.