Quantitative, three‐dimensional analysis of granule cell dendrites in the rat dentate gyrus

@article{Claiborne1990QuantitativeTA,
  title={Quantitative, three‐dimensional analysis of granule cell dendrites in the rat dentate gyrus},
  author={Brenda J. Claiborne and David G. Amaral and William Maxwell Cowan},
  journal={Journal of Comparative Neurology},
  year={1990},
  volume={302},
  url={https://api.semanticscholar.org/CorpusID:1841245}
}
The three‐dimensional organization of dentate granule cell dendritic trees has been quantitatively analyzed with the aid of a computerized microscope system. The dendrites were visualized by…
View on Wiley
ncbi.nlm.nih.gov
230 Citations
Highly Influential Citations
14
Background Citations
81
Methods Citations
23
Results Citations
20

230 Citations

Morphology of intracellularly labeled interneurons in the dentate gyrus of the immature rat

Intacellular labeling was used to assess the branching patterns of interneurons in the dentate gyrus of rat pups between 7 and 9 days of age, and most neurons were classified as GABAergic basket neurons on the basis of their dendritic morphologies.

A quantitative analysis of the dendritic organization of pyramidal cells in the rat hippocampus

These studies identified distinctive dendritic branching patterns, in the stratum radiatum and stratum lacunosum moleculare, which clearly distinguished CA3 from CAl neurons.

Intracellular labeling of dentate granule cells in fixed tissue permits quantitative analysis of dendritic morphology

Dendritic growth and regression in rat dentate granule cells during late postnatal development.

Morphology of Intracellularly Interneurons in the Dentate of the Immature Rat Labeled Gyrus

The results indicate that the dendrites and axon collaterals of dentate interneurons are extensive at a time when the principal neurons, the granule cells, are still proliferating, consistent with the idea that GABAergic interneURons may influence granule cell development in the dentate gyrus, as well as pyramidal cell maturation in the hippocampus proper.

Statistical morphological analysis of hippocampal principal neurons indicates cell‐specific repulsion of dendrites from their own cell

It was found that the dominant directional preference manifested in dendritic turns is to grow away from the soma rather than toward the incoming fibers or in any other fixed direction; therefore, B is predominant.

Neurons, numbers and the hippocampal network.

Ultrastructural features and synaptic connections of hilar ectopic granule cells in the rat dentate gyrus are different from those of granule cells in the granule cell layer

Maturation of granule cell dendrites after mossy fiber arrival in hippocampal field CA3

It is shown that dendritic outgrowth occurs before, or concurrent with, axon arrival in the CA3 target region, and that adult‐like granule neurons are present by the end of the first week.

Quantitative and morphological analysis of dentate granule cells with recurrent basal dendrites from normal and epileptic rats

Results showed that RBDs of granule cells from epileptic rats are postsynaptic to axon terminals, including mossy fibers, and thus are involved in a similar synaptic circuitry as apical dendrites of granules cells from these animals.
...

34 References

A quantitative anatomical study of the granule cell dendritic fields of the rat dentate gyrus using a novel probabilistic method

The granule cell dendritic fields of the adult rat dentate gyrus were analyzed quantitatively using a probabilistic method developed to correct dendritic length and segment number for dendrites cut…

Quantitative analysis of the dendritic branching pattern of granule cells from adult rat dentate gyrus

Differentiation of granule cell dendrites in the dentate gyrus of the rhesus monkey: A quantitative golgi study

Quanti‐tative analysis shows that, in this primate, hippocampal granule cells dif‐ferentiate mainly in the second half of gestation with all measured param‐eters attaining mature values by the time of birth, however, the analysis also reveals a transient phase of exuberant postnatal development which involves excessive dendritic branching, regional changes in dendedritic length, overproduction of dendrite spines, and redistribution of spines within the molecular layer.

Morphometric analysis of granule cell dendrites in the mouse dentate gyrus

A critical analysis of the various parameters suggests the hypothesis that the characteristic and uniform geometry of granule cell dendrites is controlled largely by factors residing in the molecular layer where growth and differentiation are sustained.

Dendritic growth and regression in rat dentate granule cells during late postnatal development.

A light and electron microscopic analysis of the mossy fibers of the rat dentate gyrus

The axon collaterals of dentate granule cells have been analyzed with the aid of a computerized microscope, following intracellular injections of horseradish peroxidase in hippocampal slice preparations, finding that they are confined to the hilar region and correlated with the location of the granule cell body.

The structural integrity of neurons in the hippocampal slice preparation as revealed by intracellular injection of Lucifer Yellow

Pyramidal neurons in the CA1 and CA3 regions and granule cells in the area dentata were identified and their processes traced and dye was observed in more than one neuron after a single neuron alone was injected.

Structure of the granular layer of the rat dentate gyrus. A light microscopic and Golgi study.

The possible role of basket cells in the regulation of the dentate gyrus granular layer was considered and several axon collaterals could be seen on the granule cell axons.

Electrical characteristics of dendrites and dendritic spines in intracellularly stained CA3 and dentate hippocampal neurons

These calculations, based on specific neuronal anatomy, predict that dendritic spines do not significantly attenuate steady-state electrical signals.

Granule cell dendritic spine density in the rat hippocampus varies with spine shape and location