Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays

@article{Brenner2000GeneEA,
  title={Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays},
  author={Sydney Brenner and Maria Q. Johnson and John A. Bridgham and George Golda and David H. Lloyd and David A. Johnson and Shujun J Luo and Sarah N. Mccurdy and Michael F. Foy and Mark Ewan and Rithy K. Roth and Dave George and Sam Eletr and Glenn Albrecht and Eric H. Vermaas and Steven R. Williams and Keith Moon and Timothy S. Burcham and Michael Pallas and Robert B. Dubridge and James F Kirchner and Karen L. Fearon and Jen-i Mao and Kevin Corcoran},
  journal={Nature Biotechnology},
  year={2000},
  volume={18},
  pages={630-634},
  url={https://api.semanticscholar.org/CorpusID:13884154}
}
A novel sequencing approach that combines non-gel-based signature sequencing with in vitro cloning of millions of templates on separate 5 μm diameter microbeads provides an unprecedented depth of analysis permitting application of powerful statistical techniques for discovery of functional relationships among genes.
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18 References

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