Search for the influence of the tyrosine hydroxylase (TCAT) n repeat polymorphism on personality traits

@article{Persson2000SearchFT,
  title={Search for the influence of the tyrosine hydroxylase (TCAT)
 n
 repeat polymorphism on personality traits},
  author={M L Persson and Danuta Wasserman and Erik G. J{\"o}nsson and Hans Bergman and Lars Terenius and Agneta Gyllander and Jack Neiman and Thomas Geijer},
  journal={Psychiatry Research},
  year={2000},
  volume={95},
  pages={1-8},
  url={https://api.semanticscholar.org/CorpusID:10631696}
}
View on Elsevier
doi.org
41 Citations
Highly Influential Citations
1
Background Citations
10
Methods Citations
2

41 Citations

Tyrosine Hydroxylase and DOPA Decarboxylase Gene Variants in Personality Traits

No strong evidence was found for the associations between personality and TH or DDC in overall tests, and an interaction effect of genotype and diagnosis was present, with TH and DDC SNPs having a greater effect on the respective personality dimensions in the group of suicide attempters.

Association study between a functional polymorphism of tyrosine hydroxylase gene promoter and personality traits in healthy subjects

No association between polymorphism in tyrosine hydroxylase and personality traits in healthy Japanese subjects

It is suggested that the (TCAT)n repeat polymorphism in the TH gene does not contribute to the personality traits evaluated on the TCI in healthy Japanese subjects.

Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals

Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes

Polymorphism in the Tyrosine Hydroxylase (TH) Gene Is Associated with Activity-Impulsivity in German Shepherd Dogs

The results have some potential to support human studies; however, further research should reveal the molecular function of the TH gene variants, and look for the effect in more breeds.

Personality and polymorphisms of genes involved in aminergic neurotransmission.

Behavioral and Brain Functions

This study investigated the DRD2, DRD3, and tyrosine hydroxylase genes in relation to personality traits in the Japanese population and found no evidence for the association between these dopamine-related genes and personality traits.

Genetic modulation of personality traits: a systematic review of the literature

No clear consensus on the role of any individual gene variant in personality modulation emerged, although SLC6A4 haplotypes and the DRD4 rs1800955 promoter variant seemed to be more reliably related to anxiety and impulsivity-related traits, respectively.

Genetic variants implicated in personality: A review of the more promising candidates

Both the theoretical and the empirical evidence implicating specific loci—in particular SERT and DRD4—in the development of personality is evaluated, and the existence of a genuine effect is argued for.

45 References

Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking

Evidence continues to support a modest role for the long alleles of the dopamine D4 receptor repeat polymorphism in the determination of NS behavior at least in some population groups.

Role of the serotonin transporter promoter polymorphism in anxiety-related traits.

The relationship of SLC6A4*C to anxiety is replicated by sibpair linkage analysis but no evidence of association is found, raising the question of whether SLC8A3*C locus is itself affecting anxiety or is linked to another still unknown functional variant.

Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking

This work provides the first replicated association between a specific genetic locus involved in neuro-transmission and a normal personality trait, the 7 repeat allele in the locus for the D4 dopamine receptor gene (D4DR).

Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism

It is indicated that the reproducibility of the association between the 5-HTTLPR polymorphism and neuroticism must be regarded as questionable and the need for a replication attempt in a large, normative sample that is stratified by ethnicity and sex is suggested.

Tyrosine hydroxylase allelic distribution in suicide attempters

Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects.

There was no main effect of genotype on harm avoidance and neuroticism scores in subjects with diagnoses of a personality disorder or substance dependence, and interactions were observed between sex and promoter system genotype and between race and promoterSystem genotype.

Possible allelic association of a tyrosine hydroxylase polymorphism with vulnerability to alcohol‐withdrawal delirium

The possible allelic association suggests that allelic variation at the TH locus mediates vulnerability to alcohol-withdrawal delirium in a small proportion of alcohol-dependent subjects.

Lithium-responsive affective disorders: no association with the tyrosine hydroxylase gene

No association between serotonin transporter gene polymorphisms and personality traits.

The previously reported association between serotonin transporter alleles and neuroticism-related personality traits could not be replicated in the present study.

Tyrosine hydroxylase and dopamine D4 receptor allelic distribution in Scandinavian chronic alcoholics.

Results suggest that no major influence on alcoholism is exerted through genes associated with the DRD4 or TH allelic markers examined, and polymorphic genetic markers at the tyrosine hydroxylase (TH) and dopamine D4 receptor (DRD4) loci were examined in Scandinavian chronic alcoholics.